中文簡(jiǎn)介

BBA一般受試者接受提交原始的、假設(shè)驅(qū)動(dòng)的研究或評(píng)論，這些研究或評(píng)論涉及生物化學(xué)和生物物理領(lǐng)域的受試者，這些學(xué)科被認(rèn)為對(duì)廣泛的受眾具有普遍興趣。特別鼓勵(lì)采用跨學(xué)科方法的手稿。首選主題包括醫(yī)學(xué)上重要的生物化學(xué)/生物物理研究和新興領(lǐng)域，如納米生物學(xué)（納米粒子、納米毒理學(xué)、納米醫(yī)學(xué)）、系統(tǒng)生物學(xué)（基因組學(xué)、蛋白質(zhì)組學(xué)、脂質(zhì)組學(xué)、糖組學(xué)、基于實(shí)驗(yàn)方法的生物信息學(xué)）、化學(xué)生物學(xué)（化學(xué)化合物、藥物機(jī)制、合成新的化合物，點(diǎn)擊化學(xué)），結(jié)構(gòu)生物學(xué)（結(jié)晶學(xué)，核磁共振，多聚蛋白質(zhì)，蛋白質(zhì)動(dòng)力學(xué)），新的復(fù)合物（純天然化合物，合成化合物，蛋白質(zhì)復(fù)合物，核酸衍生物），細(xì)胞信號(hào)傳導(dǎo)（受體信號(hào)，蛋白質(zhì)磷酸化級(jí)聯(lián)，磷酸酶，二級(jí)信使，轉(zhuǎn)錄調(diào)節(jié)因子糖化、基因表達(dá)）、糖生物學(xué)（糖代謝產(chǎn)物和代謝、糖基化蛋白、膜蛋白、糖基化、糖代謝）、氧化還原生物學(xué)（氧化還原開(kāi)關(guān)、谷胱甘肽和硫氧還蛋白系統(tǒng)、氧和氮自由基物種、超氧化物、過(guò)氧化氫、羥基自由基、一氧化氮、過(guò)氧化物、缺氧、氧化還原調(diào)節(jié)轉(zhuǎn)錄因子）、神經(jīng)生物學(xué)（神經(jīng)元生長(zhǎng)因子和神經(jīng)信號(hào)傳導(dǎo)、膠質(zhì)細(xì)胞、自主神經(jīng)和中樞神經(jīng)系統(tǒng)）、干細(xì)胞（分化、干細(xì)胞分離和培養(yǎng)、生長(zhǎng)因子）、具有生化重要性和一般意義的化合物的成像方法學(xué)和機(jī)械特性（藥物先導(dǎo)），有毒物質(zhì)，營(yíng)養(yǎng)物質(zhì)，代謝物）。作者必須在提交時(shí)提供一句話(huà)，說(shuō)明原稿中描述的工作對(duì)廣大讀者具有普遍意義和興趣的原因。聲稱(chēng)新穎性還不夠。作者聲明將作為審查過(guò)程中的一個(gè)輔助，并將包括在接受的論文的最終版本中，以確定BBA一般主題的讀者的方向。

　　英文簡(jiǎn)介

BBA General Subjects accepts for submission either original, hypothesis-driven studies or reviews covering subjects in biochemistry and biophysics that are considered to have general interest for a wide audience. Manuscripts with interdisciplinary approaches are especially encouraged.Preferred topics include medically important biochemistry/biophysics research and emerging areas such as nanobiology (nanoparticles, nanotoxicology, nanomedicine), systems biology (genomics, proteomics, lipidomics, glycomics, bioinformatics based on experimental approaches), chemical biology (chemical compounds, drug mechanisms, synthesis of novel compounds, click chemistry), structural biology (crystallography, NMR, multimeric proteins, protein dynamics), novel complexes (pure natural compounds, synthetic compounds, protein complexes, nucleic acid derivatives), cellular signaling (receptor signaling, protein phosphorylation cascades, phosphatases, secondary messengers, transcription regulation, gene expression), glycobiology (sugar metabolites and metabolism, glycosylated proteins, membrane protein, glycosylation, glycomics), redox biology (redox switches, glutathione and thioredoxin systems, oxygen and nitrogen radical species, superoxide, hydrogen peroxide, hydroxyl radical, nitric oxide, peroxides, hypoxia, redox regulation of transcription factors), neurobiology (neuronal growth factors and nerve signaling, glial cells, autonomic and central nervous systems), stem cells (differentiation, stem cell isolation and cultivation, growth factors), imaging methodologies and mechanistic characterization of compounds having biochemical importance and general interest (drug leads, toxicants, nutrients, metabolites).Authors must provide a sentence at submission stating the reason that the work described in the manuscript has general significance and interest to a wide audience. Claims of novelty do not suffice. The author statement will be used as an aid in the reviewing process and will be included in the final version of the accepted paper to orient readers of BBA General Subjects.

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